Large Block Owners	309
Total Number of Shares Held	45.1M

% Change in Ownership	-1%
% Shares Owned	76%

Monthly Rotation	Number of Shares	Value of Change (MM)	% of Shrs. Outstanding
Buyers 11/22/09	7,663,829	$38.81	41.9%
Sellers 11/22/09	11,677,453	$77.57	28.9%

Institutions:
90 Holders
$114,001,608 Value
53.3% Owned of O/S

Mutual Funds:
126 Holders
$30,960,856 Value
14.1% Owned of O/S

Other Major Holders:
93 Holders
$114,349,312 Value
53.4% Owned of O/S

53.1% 0.6% 0.1%

Concentration of Current % Held

Top 10 Institutions:

Top 20 Institutions:

Top 50 Institutions:

All:

Moderate
Avg. Turnover Rating

Name	Shares Held	Position Value	Percentage of Total Holdings since 11/22/09	% Owned of Shares Outstanding	Turnover Rating
Barbier (Remi)	6.6M	$33,236,821	+22%	15.5%	Low
Eastbourne ...	3.2M	$16,377,134	+11%	7.7%	High
Visium Capital ...	2.7M	$13,519,050	+9%	6.3%	High
Barclays Global ...	2.3M	$11,399,578	+8%	5.3%	Low
Park West Asset ...	1.9M	$9,600,308	+6%	4.5%	High
Renaissance ...	1.7M	$8,635,634	+6%	4.0%	High
Biotechnology ...	1.7M	$8,435,020	+6%	4.0%	Moderate
Vanguard Group, Inc.	1.6M	$7,887,326	+5%	3.7%	Low
Dimensional Fund ...	1.1M	$5,323,019	+4%	2.5%	Low
GAMCO Investors, ...	1.0M	$5,085,300	+3%	2.4%	Low

Percentage of Outstanding Shares per Holdings Style (Top 10)

Index 8.7%

GARP 1.4%

Core Value 0.5%

Growth 0.4%

Core Growth 0.3%

Aggres. Gr. 0.1%

Sector Specific 0.1%

Specialty 0.1%

Income Value 0.1%

Yield 0.0%

Moderate
Avg. Turnover Rating

Name	Shares Held	Position Value	Percentage of Total Holdings since 11/22/09	% Owned of Shares Outstanding	Investment Style
Vanguard Total ...	514.9K	$2,764,949	+2%	1.2%	Index
Vanguard ...	435.8K	$2,340,096	+1%	1.0%	Index
iShares Russell ...	418.4K	$2,246,969	+1%	1.0%	Index
DFA U.S. Micro ...	410.9K	$1,808,000	+1%	1.0%	Index
iShares NASDAQ ...	330.6K	$1,673,074	+1%	0.8%	Index
Vanguard ...	276.1K	$1,482,732	+1%	0.7%	Index
Gabelli Small ...	265.0K	$1,423,050	+1%	0.6%	GARP
iShares Russell ...	244.4K	$1,312,347	+1%	0.6%	Index
CREF Stock Account	170.7K	$916,659	+1%	0.4%	Index
Vanguard ...	147.2K	$790,260	0%	0.4%	Index